|
|
|
|
2011 Taiwan-America Science and Technology Conference
Department of Chemical and Biomolecular Engineering URL: http://164.67.192.163:81/labmembers.aspx Professor Liao is Chancellor's Professor and Vice Chair of Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA). He is a pioneer in Metabolic Engineering, Synthetic Biology, and Systems Biology. He received his B.S. degree from the National Taiwan University and Ph.D. degree in at University of Wisconsin-Madison in 1987. After working as a research scientist at Eastman Kodak Company in Rochester, N.Y., he started his academic career at Texas A&M University in 1990 and moved to UCLA in 1997. He was elected Fellow of the American Institute for Medical and Biological Engineering in 2002 and has received numerous awards including the NSF Young Investigator Award (1992), Merck Award for Metabolic Engineering (2006), FPBE Division award of American Institute of Chemical Engineers (AIChE) (2006), Charles Thom Award of the Society for Industrial Microbiology (2007), Marvin J. Johnson Award of the American Chemical Society (2009), Alpha Chi Sigma Award of AIChE (2009), James E. Bailey Award of the Society for Biological Engineering (2009), and Presidential Green Chemistry Challenge Award (2010). Professor Liao and his research group are focusing on elucidating and reconstructing biological regulatory networks at the systems level. Experimental and computational methods are being developed to understand, predict, and redesign cellular behavior. An integrative technique called Network Component Analysis (NCA) have been developed which utilizes mRNA expression and transcriptional network connectivity to determine network component dynamics, functions, and interactions. This approach has been applied to elucidate transcription factor dynamics in Saccharomyces cerevisiae cell-cycle regulation, detect cross-talks in Escherichia coli two component signaling pathways, and characterize E. coli carbon source transition. In addition, novel synthetic gene-metabolic circuits have been designed and constructed to demonstrate system-wide understanding of cellular regulation. To this end, artificial feedback regulation, cell-cell communication, and oscillatory circuits have been constructed, which demonstrate the design principles of gene-metabolic regulation in the cell.
2011 Taiwan-America Science and Technology Conference Biosynthesis of higher alcohols Prof. James C. Liao Abstract
|
